Pharmacology & ToxicologyBiomoleculesPeer-reviewed
Hyperactivity in mice induced by opioid agonists with partial intrinsic efficacy and biased agonism; alone and in combination with morphine
Agnes Acevedo‐Canabal, Travis W. Grim, Cullen L. Schmid…·Laura M. Bohn
The paper shows that noncompetitive MOR agonists reduce morphine-induced hyperactivity while enhancing pain relief, and that receptor-level intrinsic efficacy does not directly correlate with locomotor activity.
11 citations