Michelle A. Loprieno

This study shows that restricting meganuclease expression to specific tissues reduces off-target gene editing in vivo.

This study demonstrates that a viral gene drive can spread in vivo during HSV-1 infection in mice by promoting co-infection and recombination.

This study shows that AAV-delivered gene editing reduces latent HSV DNA in mice and decreases viral shedding, with some toxicity observed at high doses.