Jack W. Houghton

This paper develops the first cell-active covalent inhibitors of RAB27-effector interactions, showing enantioselectivity and improved potency over a previously reported toxic compound.

This paper identifies a phosphorylation-dependent mechanism that regulates splice variant-specific S-palmitoylation of Kv4.3, showing how phosphorylation at S538 primes palmitoylation at C546/547 and modulates channel function.

This study identifies RUVBL1/2 as a host ATPase essential for rhinovirus replication and shows that its inhibition effectively blocks viral replication without resistance development.

This paper introduces a high-throughput activity proteomics pipeline for discovering deubiquitinase inhibitors, identifying potent and selective inhibitors with minimal optimization.

This study uses APEX2 proteomics to map the spatiotemporal interactome of the luteinizing hormone receptor (LHR) and identifies novel interactors like RAP2B that modulate receptor signaling and trafficking.

A whole genome multiparametric CRISPR screen in progeria identifies new pathways that can reverse cellular aging phenotypes by targeting protein translation and related processes.

The paper introduces a chemical genetic system to map ZDHHC-specific S-acylation substrates at the whole proteome level in intact cells.