The translatome of quiescent Plasmodium falciparum gametocytes reveals parasite pyridoxal 5'-phosphate (PLP) biosynthesis is essential for efficient mosquito stage development
Eduardo Alves, Jack W. Houghton, Lindsay B. Stewart…·Michael J. Delves
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London School of Hygiene & Tropical MedicineORCID 0000-0002-9003-0160Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
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Eduardo Alves, Jack W. Houghton, Lindsay B. Stewart…·Michael J. Delves
Samuel Palmer, Balotin Fogang, Lindsay B. Stewart…·David J. Conway
The paper identifies large deletion variants in the PIMMS43 gene of Plasmodium falciparum and shows their geographic frequency variation and potential vector-specific selection.
Lindsay B. Stewart, James Philpott, Gordon A. Awandare, David J. Conway
The paper investigates whether variation in multiplication rates of Plasmodium falciparum isolates under competitive conditions is determined by their intrinsic potential, finding a strong correlation with exponential growth rates.
Elena Lantero, Lindsay B. Stewart, Balbir Bagicha Singh…·David J. Conway
The paper compares transcript levels of invasion ligand genes in Malaysian and Gambian Plasmodium falciparum isolates, finding regional differences in eba175, eba181, and Rh2b expression.
Lindsay B. Stewart, Elena Lantero, James Philpott…·David J. Conway
The paper examines intrinsic multiplication rates of Plasmodium falciparum in Malaysian clinical isolates, finding no significant difference compared to African isolates, suggesting no adaptation to low transmission settings.
Lindsay B. Stewart, Elena Lantero, James Philpott…·David J. Conway
This study compares Plasmodium falciparum multiplication rates between hospital and community infections, finding higher rates in hospital isolates and a positive correlation with parasitaemia.
Aline Freville, Lindsay B. Stewart, Kevin K.A. Tetteh…·David J. Conway
Hyun Jae Lee, Michael Walther, Athina Georgiadou…·Aubrey J. Cunnington
This study uses dual transcriptome analysis to identify host and parasite gene expression associated with severe malaria in Gambian children, showing parasite load explains most human gene expression differences but only a third of parasite gene differences.