Michaël Schubert

This study shows that chromosome 7 gain optimizes WNT signaling in colorectal cancer by counteracting excessive stemness from APC mutations.

This study shows that TET2 loss increases lymphoma penetrance and promotes survival of premalignant B cells in MYC-driven lymphoma by reducing apoptosis.

This study shows p53 inactivation is not universally linked to aneuploidy but is associated with increased chromosome loss in cancer.

The paper identifies ARGOS genes, which are amplified in cancer, have low expression relative to copy number, and are toxic when overexpressed, and validates several as pan-cancer targets.

This study shows that aneuploid cancer cells adapt by reducing chromosomal instability and inflammation, with KRAS amplification aiding this adaptation.

epiAneufinder identifies copy number variations from scATAC-seq data to explore single-cell CNV heterogeneity in cancer samples.

The paper identifies HDAC4 as a synthetic lethal target in MELK-overexpressing cancers through a yeast screen and mammalian validation.

The paper shows that gene regulatory networks inferred from cancer data are heavily influenced by aneuploidies and sample impurities, with up to 80% of edges potentially due to these factors.

The paper quantifies proteomic and genomic variation in colorectal cancer cell lines to understand how mutations affect protein levels and drug responses.