Heather Hulme

The paper identifies differentially expressed genes in specific brain regions of germ-free mice, highlighting microbiome influence on brain gene expression and potential relevance to neurological disease.

SMEW provides a code-free, interactive platform for analyzing spatial metabolomics data across multiple scales and conditions to identify metabolic patterns and biological pathways.

This study investigates the systemic effects of microbiome-derived carnitine analogues in mice, showing carnitine depletion and mitochondrial dysfunction due to inhibition of carnitine biosynthesis.

This study identifies a reversible basal-like cell state in AKT-inhibitor resistant triple negative breast cancer using multimodal profiling and lineage tracing.

This study uses spatial biology to identify intestinal and systemic molecular drivers of inflammation in DSS-treated mice, revealing new insights into IBD-related systemic effects.

The paper isolates and characterizes novel Clostridium XIVa strains from the murine gut, revealing genomic diversity driven by mobile genetic element acquisition and expanded biosynthetic potential.