Leo Y. T. Chou

The paper introduces origamiFISH-Flow, a high-throughput, label-free method for detecting DNA origami in single-cell suspensions, showing improved sensitivity and enabling cell-type-specific uptake profiling.

origamiFISH enables label-free, single-molecule detection of DNA origami nanostructures in cells and tissues, revealing cell-type and shape-specific uptake patterns at low concentrations.

The paper demonstrates the use of nucleic-acid-based transcription factors to implement complex transcriptional logic in cell-free systems.