Aniliese Deal

This study investigates the evolutionary transition of fungi from land to sea using Kluyveromyces yeasts, finding genome size reduction, phenotypic changes, and positive selection in marine species.

This study identifies an allosteric mechanism in eIF2B that regulates the Integrated Stress Response by showing how eIF2-P binding inhibits eIF2B activity through latch-helix dislocation.

This study identifies molecular and genetic features underlying stress resistance in the extremotolerant yeast Kluyveromyces marxianus through omic profiling and evolutionary analysis.

The paper demonstrates that a modified ISRIB analog selectively targets a mutant eIF2B, improving synaptic plasticity and memory in mice, confirming its on-target mechanism.