Stine F. Pedersen

The paper develops SurpHer, a genetically encoded ratiometric pH sensor, and demonstrates its use in imaging extracellular pH dynamics in human cells and tumor microenvironments.

This paper identifies NBCn1 as a ciliary membrane component that regulates ciliary length and Sonic hedgehog signaling through interactions with DYNLL1 and SUFU.

The paper presents the cryo-EM structure of HsNHE6, revealing its dimeric architecture, ion-binding site, and lipid-stabilized gate, along with insights into its disordered C-terminus and functional roles in ion exchange and disease.

This paper introduces a microfluidic device that creates oxygen and pH gradients to study their effects on cancer and stromal cells in the tumor microenvironment.

This study shows that acidic tumor environments enhance pancreatic cancer stem cell properties and metastasis in mice.

This study shows DLG1 regulates ciliary protein trafficking in kidney cells, with loss of DLG1 causing ciliary elongation and cysts, and a specific DLG1 variant linked to kidney disease.