BiochemistryCell DiscoveryPeer-reviewed
A framework for Frizzled-G protein coupling and implications to the Wnt-PCP signaling pathways
Zhibin Zhang, Xi Lin, Ling Wei…·Fei Xu
This study presents cryo-EM structures of FZD6, FZD3, and FZD1 in active and inactive states, revealing a shared activation framework and potential crosstalk between G-protein binding and Wnt-PCP signaling.