Gerhard Leinenga

The paper shows that ultrasound treatment improves memory in AD mice without reducing amyloid-β, with higher frequency (1 MHz) being more effective than lower frequencies.

The paper analyzes the transcriptomic response of microglia in an Alzheimer's disease mouse model treated with scanning ultrasound, identifying differentially expressed genes and pathways related to phagocytosis and cell cycle activation.

This study demonstrates that focused ultrasound with microbubbles enhances the delivery of Aducanumab and anti-Tau antibodies across a human sporadic Alzheimer's disease blood-brain barrier model.

The paper demonstrates that pre-incubating BBB models with claudin-5 binders enhances FUS-mediated BBB opening, allowing lower acoustic pressures and improved permeability.

This study compares the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in APP23 mice, finding that both reduce plaques and that the combination improves spatial memory.