Cell BiologybioRxivPreprint
Ubiquitin ligase CHFR impairs Tie2 signaling via K48-linked ubiquitylation and degradation of Akt1 in endothelial cells
Mohammad Owais Ansari, Gary C. H. Mo, Lasanthi Jayathilaka…·Chinnaswamy Tiruppathì
This study identifies CHFR as a regulator of endothelial inflammatory responses by promoting Akt1 ubiquitylation and degradation, thereby impairing Tie2 signaling and endothelial barrier integrity.