Yusuke Nasu

The paper develops Ca2+-independent lactate biosensors for multiplexed in vivo imaging of extracellular lactate dynamics alongside neuronal activity.

The paper introduces OCaMP, an orange fluorescent calcium indicator that improves sensitivity and performance compared to existing green and red indicators for neural imaging.

The paper investigates how stress affects activity levels through interactions between orexin neurons and astrocytes, finding that astrocytic glucocorticoid receptors mediate sex-specific changes in neuronal firing and activity.

This paper develops a photocaged lactate derivative to locally perturb lactate concentrations and study its roles in metabolism and signaling.

The paper introduces a mouse line for labeling blood and interstitial fluid with fluorescent proteins to study vascular structure and permeability in vivo.

The paper shows lactate-dependent glycolysis shifts produce D-serine, linking astrocyte metabolism to synaptic and cognitive functions through CB1 receptor activation.

This paper develops improved fluorescent biosensors for monitoring extracellular and intracellular L-lactate in mammalian cells, showing enhanced sensitivity and response kinetics.

This paper develops a genetically encoded fluorescent biosensor for extracellular L-lactate and demonstrates its use in imaging in cultured mammalian cells and brain tissue.