Aleksey Porollo

SPPIDER-seq predicts protein-protein interaction sites by considering partner-specific context, outperforming AlphaFold3 on disordered interfaces and revealing partner-specific patterns in TP53 interactions.

The paper identifies a new bZIP protein motif, BPabZIP, that facilitates nucleosome displacement and binding near nucleosomes in human cells.

This study uses scRNA-seq to map the life cycle of Pneumocystis carinii, identifying transcriptional states associated with developmental stages and reproductive transitions.

The paper identifies rare FOXF1 missense variants in PAH patients, shows dysregulated FOXF1 expression in PAH lungs, and identifies downstream targets linked to PAH pathogenesis.

This study identifies NLRP3 inflammasome activation and NETosis in P. murina pneumonia, highlighting neutrophils' role in inflammation and tissue damage.