Margarita Menéndez

This study presents cryo-EM structures of the Bag1-bound 26S proteasome, revealing a mechanism for ubiquitin-independent proteasomal degradation through conformational changes in the 19S regulatory particle.

The paper reports the crystal structure of MtbEccC5DUF and shows it lacks ATPase activity, suggesting it may function in hexamerization during secretion.

The paper compares the amyloid-like assembly mechanisms of CPEB prion-like domains from Aplysia and Drosophila, showing divergent pathways leading to a common fold.