Albert Galera‐Prat

The paper identifies a Tankyrase scaffolding inhibitor, S8 (ARCher-142), that selectively targets the ARC4 peptide binding domain with 8 µM potency.

This study identifies serine residues in PARP2's N-terminus as targets of automodification, showing their role in PARP2 release from DNA damage sites via PARylation.

This study identifies C-8 position substitutions in quinazolin-4-ones that enhance the potency and selectivity of tankyrase inhibitors by improving interactions with TNKS2.

This study develops a FRET-based high-throughput screening assay to identify inhibitors of PARP1/2-HPF1 interaction, discovering two compounds with μM potency.

This study investigates the evolutionary origin and conservation of tankyrases across species, showing their presence in choanoflagellates and conservation of core functions despite varying interaction partners.

The paper compares the amyloid-like assembly mechanisms of CPEB prion-like domains from Aplysia and Drosophila, showing divergent pathways leading to a common fold.