GeneticsbioRxivPreprint
Ancient human genomes from Ladakh reveal Tibetan, South Asian, and Central Asian admixture over the last three millennia
DOI 10.64898/2026.01.26.701789
Author
David Witonsky
University of ChicagoORCID 0000-0002-3274-9003Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2018-2026 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 20 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship7 papers
Recent·Most cited
- GenomicsPLoS GeneticsPeer-reviewed
Genomic profiling of active vitamin D colonic responses in African- and European-Americans identifies an ancestry-related regulatory variant of POLB
David Witonsky, Bharathi Laxman, Hina Usman…·Sonia S. Kupfer
The paper identifies an ancestry-related regulatory variant of POLB associated with 1,25D responses in colonic organoids from African- and European-Americans.
1 citation - GenomicsbioRxivPreprint
Comparative transcriptomics of iPSC-derived cardiomyocytes in a high and a low altitude population
OA Gray, David Witonsky, Anna Di Rienzo
The paper compares transcriptomes of iPSC-derived cardiomyocytes from Tibetan and Han Chinese populations under hypoxia, identifying pathway differences linked to high-altitude adaptation.
DOI 10.1101/2025.06.04.657917 - GeneticsHuman Genetics and Genomics AdvancesPeer-reviewed
Distinct positions of genetic and oral histories: Perspectives from India
Arjun Biddanda, Esha Bandyopadhyay, Constanza de la Fuente Castro…·Maanasa Raghavan
The paper compares genetic and oral histories of four Indian populations, finding genetic similarity to other Indian groups but no evidence of additional non-local genetic sources.
4 citations - GenomicsbioRxivPreprint
Poverty shapes the transcriptome of immune cells
Nicole S. Arnold, Justyna Resztak, David Witonsky…·Francesca Luca
The paper identifies 138 genes differentially expressed in blood immune cells associated with poverty, enriched in wound healing and coagulation, and linked to hypertension.
DOI 10.1101/2022.12.06.517536 - GenomicsScience AdvancesPeer-reviewed
The genetic prehistory of the Andean highlands 7,000 Years BP though European contact
John Lindo, Randall Haas, Courtney A. Hofman…·Anna Di Rienzo
The paper analyzes ancient DNA from the Andes to reveal genetic adaptations and population dynamics over 7,000 years, showing a split between high and lowland populations and a severe post-European-contact collapse.
166 citationstop 1% - GeneticsPLoS GeneticsPeer-reviewed
Detecting past and ongoing natural selection among ethnically Tibetan women at high altitude in Nepal
Choongwon Jeong, David Witonsky, Buddha Basnyat…·Anna Di Rienzo
The paper identifies genetic evidence of positive and negative selection in Tibetan women from Nepal related to reproductive traits and offspring survival.
86 citationstop 4%