Anjaparavanda P. Naren

The paper investigates the interaction between T2R14 and CFTR, showing agonist-dependent physical coupling and Gq signaling in response to microbial signals.

This study identifies LPCAT1 as a critical regulator of AT2 cell renewal and lipid metabolism in IPF, showing that reactivating LPCAT1 can mitigate lung fibrosis.

The paper identifies SCCPDH as an off-target of VX-445 using a photoaffinity ligand and chemoproteomics, showing metabolic dysregulation and potential clinical implications.

This study identifies CFTR-related defects in idiopathic pancreatitis and shows that ivacaftor can reverse these defects in patient-derived models.

The paper compares genetic and oral histories of four Indian populations, finding genetic similarity to other Indian groups but no evidence of additional non-local genetic sources.

This study investigates the role of CFTR in conductive hearing loss by analyzing middle ear cell composition and gene expression in CF and WT mice.

The paper constructs a single-cell reference atlas for human and mouse lung tissues to improve cell type annotation and data integration.

The paper identifies PP-2, a src-kinase inhibitor, as a novel corrector for ΔF508-CFTR in cystic fibrosis through in silico screening and experimental validation.