Author

Adam J. Brown

University of SheffieldORCID 0000-0002-3290-4560Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Edward CurryiD· 2 shared Melinda PohleiD· 2 shared Bernadette M. Sweeney· 1 shared Cristina N. Alexandru-Crivac· 1 shared Daniel K. FabianiD· 1 shared David C. JamesiD· 1 shared George Muir· 1 shared Harry Allsopp· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioengineering

Edward CurryORCID

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Author profile →

3 papers

Recent·Most cited

BioengineeringNucleic Acids ResearchPeer-reviewedJul 19, 2025

Synthetic G-quadruplex components for predictable, precise two-level control of mammalian recombinant protein expression

Melinda Pohle, Edward Curry, Ryan Holden…·Adam J. Brown

This paper develops synthetic G-quadruplex elements to precisely control mammalian recombinant protein expression across different hosts and molecular formats.

4 citations

humanexperimental assay

𝕏 PostBluesky

BioengineeringbioRxivPreprintJun 27, 2024

Large-Scale Comparative Transcriptomic Analysis of CHO Cell Functional Adaptation to Recombinant Monoclonal Antibody Production

Cristina N. Alexandru-Crivac, Joseph F. Cartwright, R. M. Taylor…·David C. James

The paper compares transcriptomic changes in CHO cells producing different recombinant mAbs, finding adaptive mRNA abundance changes linked to mAb production and cellular capacity.

1 citation

mousebulk RNA-seq

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BioengineeringBiotechnology JournalPeer-reviewedJun 1, 2024

Expanding the RNA polymerase biocatalyst solution space for mRNA manufacture

Edward Curry, Svetlana E. Sedelnikova, John B. Rafferty…·Adam J. Brown

This paper expands the RNA polymerase biocatalyst solution space for mRNA manufacture by identifying and validating eight novel RNAPs and their promoters through a high-throughput screening platform.

9 citations

bulk RNA-seqdeep learning

𝕏 PostBluesky