Author

Edward N. Pugh

University of California, DavisORCID 0000-0002-3293-6538Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 3 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 3 Assay:electrophysiology· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Gabriel PeinadoiD· 3 shared Kaitryn E. RonningiD· 2 shared Marie E. BurnsiD· 2 shared Prescott C. AlexanderiD· 2 shared Connor E. WeissiD· 1 shared David John CalkinsiD· 1 shared Debarshi MustafiiD· 1 shared Joseph CarrolliD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiophysics

Gabriel PeinadoORCID

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Author profile →

4 papers

Recent·Most cited

NeurosciencebioRxivPreprintMay 1, 2026

Optoretinography in R9AP-bradyopsia reveals the essential role of G-protein signaling in the human cone elongation response

Connor E. Weiss, Teng Liu, Vimal Prabhu Pandiyan…·Ramkumar Sabesan

This study uses optoretinography in R9AP-bradyopsia patients to show that G-protein signaling is essential for the human cone elongation response.

DOI 10.64898/2026.04.28.721497

𝕏 PostBluesky

BiophysicsbioRxivPreprintNov 9, 2025

Biophysical Basis of the in vivo ERG of the Mouse: Rod, RPE and Müller glial Cell Contributions To Dark and to Light-driven Changes in Sub-Retinal Space o

Gabriel Peinado, Prescott C. Alexander, Kaitryn E. Ronning…·Edward N. Pugh

The paper measures ERGs in mice to assess contributions of rod, RPE, and Müller glial cells to dark and light-driven changes in sub-retinal space ion concentrations.

DOI 10.1101/2025.11.09.687427

mouseelectrophysiology

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BiophysicsbioRxivPreprintFeb 5, 2025

Biophysical Basis of the in vivo Electroretinogram of the Mouse: Current Source Density Analysis of Genetically and Pharmacologically Isolated Rod photoreceptor-driven Currents

Gabriel Peinado, Prescott C. Alexander, Kaitryn E. Ronning…·Edward N. Pugh

The paper develops a biophysical model of rod photoreceptors in mice to analyze the electroretinogram (ERG) a-wave, confirming that extracellular capacitive current and HCN1 channel activity shape the a-wave's relaxation and plateau.

1 citation

mouseelectrophysiology

𝕏 PostBluesky

BiophysicsbioRxivPreprintJan 28, 2025

Biophysical Basis of the in vivo Electroretinogram of the Mouse: 4-Shell Current Source Density Model

Gabriel Peinado, Ratheesh Kumar, Vincent Yao…·Edward N. Pugh

The paper develops a 4-shell current source density model to explain the biophysical basis of the in vivo electroretinogram in mice, showing it better explains ERG waveforms than the classic Rodieck-Ford model.

2 citations

mouseelectrophysiology

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