Caleb R. Glassman

This paper shows IL-23 licenses Th17 cells for transdifferentiation into pathogenic effectors by upregulating IL-12Rβ2 via STAT4, revealing a stepwise mechanism involving IL-23 and IL-12.

This study identifies IL-2-induced Stat3 signaling as essential for programming iTreg cells to differentiate into eTreg cells and achieve IL-10 transcriptional competency.

The paper introduces a 3-track network for accurate protein structure and interaction prediction, achieving performance close to DeepMind's CASP14 results and enabling rapid modeling of protein complexes from sequence data.