Matthew T. Eddy

The paper investigates how lipid organization in nanodiscs affects GPCR conformational states, finding that anionic lipid concentration thresholds vary between POPS and POPG.

This study compares the conformational equilibria of the human A2A adenosine receptor in lipid vesicles and aqueous solutions using 19F-NMR, revealing environment-dependent differences in agonist-bound states.

This study investigates how disease-associated mutations in G protein subunits affect nucleotide interactions using spectroscopic and computational methods, revealing distinct structural and functional changes.

This study investigates how temperature affects the conformational landscape of the A2A adenosine receptor, showing drug efficacy and membrane mimetic dependence.