Edward R. Lyman

The paper shows that ether linkages in phospholipids modulate membrane mechanics and topology through distinct physical mechanisms, explaining their evolutionary conservation and biological roles.

The paper investigates how lipid organization in nanodiscs affects GPCR conformational states, finding that anionic lipid concentration thresholds vary between POPS and POPG.

The paper develops an investigator-blind analysis pipeline to identify structural elements controlling GPCR function using molecular dynamics simulations and finds known microswitches and two potential new motifs.

This paper uses simulations to show that highly ordered lipid bilayers exhibit glass-like dynamics with soft fluid channels, which may facilitate molecular interactions.

This study shows that hopanoids and sterols modulate lipid ordering differently based on phospholipid acyl chain unsaturation position, with cholesterol providing broader ordering effects than diplopterols.

This study investigates how temperature affects the conformational landscape of the A2A adenosine receptor, showing drug efficacy and membrane mimetic dependence.

The paper reveals that mammalian plasma membranes have phospholipid imbalances due to cholesterol asymmetry, affecting membrane permeability and protein localization.

The paper shows that running in mice changes spontaneous neural activity in the olfactory bulb, increasing population entropy and suggesting higher-order neuron interactions during locomotion.