James E.C. Jepson

This study shows that nighttime sleep in Drosophila is necessary for mechanosensory habituation, likely by promoting synaptic downscaling.

This study shows that micro- and nano-plastics worsen Parkinson's Disease-like symptoms in a fruit fly model with mitochondrial defects.

This study identifies acetylcholinesterase inhibitors as potential treatments for paroxysmal dyskinesia by rescuing motor defects in a Drosophila model with BK channel gain-of-function.

The paper identifies biallelic variants in ARHGAP19 as a cause of motor-predominant neuropathy with conduction slowing in multiple families.

This study links proteotoxic stress from defective autophagy to epileptogenesis in Drosophila and Vici Syndrome patients, suggesting autophagy-stimulating diets as a potential treatment.

This study shows that gain-of-function BK channel mutations disrupt limb control in fruit flies by altering neuronal development during a critical period, not by affecting mature circuits.

This study creates a Drosophila model with a hSlo1 D434G mutation, showing motor dysfunction and altered action potentials linked to BK channel gain-of-function.

This study examines how a BK channel mutation affects synaptic plasticity and motor circuits in Drosophila larvae, finding altered neurotransmitter release and CPG dysfunction.

The paper shows JETLAG and the DYSCHRONIC-SLOWPOKE complex antagonistically regulate circadian output and synaptic development in Drosophila.

This study identifies a circuit in Drosophila where DN1p neurons integrate circadian, homeostatic, and environmental cues to regulate sleep onset.

This study identifies Neurocalcin's role in promoting sleep by inhibiting a movement-promoting neural network in Drosophila.

This study investigates how mutations in Membrin/GOSR2 affect dendritic growth and synaptic integrity in Drosophila models, revealing their role in neurological disorders.

This study identifies RFVT gene mutations in BVVLS, shows mitochondrial dysfunction, and demonstrates therapeutic potential with riboflavin esters.

This study identifies a thermo-sensitive circuit in Drosophila that delays daytime siesta onset in response to elevated temperatures.