Takuya Terai

The paper develops a new calcium indicator, HiCaRI, based on the photostable mStayGold protein, showing improved brightness and photostability compared to existing GFP-based indicators.

This paper introduces a biosensor-based method for single-molecule enzyme activity profiling without enzyme-specific substrates, enabling absolute quantification of active enzyme molecules in cellular and circulating samples.

The paper develops a photostable pH biosensor called serapH using mStayGold as a scaffold and introduces a screening method for pH-sensitive FPs in bacterial colonies.

The paper introduces OCaMP, an orange fluorescent calcium indicator that improves sensitivity and performance compared to existing green and red indicators for neural imaging.

The paper introduces PinkyCaMP, a new red fluorescent calcium sensor with improved brightness, photostability, and compatibility with optogenetics and neurotransmitter imaging.

The paper develops high-performance green and red fluorescent biosensors for pyruvate with large fluorescence intensity changes and varying affinities, enabling multicolor imaging in mammalian cells.

This paper introduces two new far-red fluorescent GECIs, FR-GECO1a and FR-GECO1c, characterized for their Ca2+ sensitivity and performance in neuronal imaging.

This paper develops a photocaged lactate derivative to locally perturb lactate concentrations and study its roles in metabolism and signaling.