Author

Michal Grulich

Czech Academy of SciencesORCID 0000-0002-3434-4958Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrea PalyzováiD· 1 shared Bartłomiej SurpetaiD· 1 shared Helena MarešováiD· 1 shared Jan BrezovskýiD· 1 shared Jiří ZahradníkiD· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperBiochemistry

Andrea PalyzováORCID

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1 paper

Recent·Most cited

BiochemistrybioRxivPreprintMay 9, 2023

Engineering dynamic gates in binding pocket of penicillin G acylase to selectively degrade bacterial signaling molecules

Michal Grulich, Bartłomiej Surpeta, Andrea Palyzová…·Jan Brezovský

This paper designs engineered variants of penicillin G acylase to selectively degrade bacterial signaling molecules, showing significant shifts in substrate specificity.

1 citation

bacteria (other)proteomics

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