Jan Bieschke

The paper identifies novel Taf1 transcripts and protein distribution in mouse, revealing transcriptional diversity and elevated expression in cerebellum.

This study identifies VCP as a suppressor of proteopathic seeding and shows that VCP dysfunction increases seeding of multiple aggregates, contributing to neurodegeneration.

This study identifies TDP-43 oligomers as early intermediates in aggregation, showing ALS-linked mutations accelerate this process and enhance aggregate propagation.