Jennifer H. Lawrence

This study shows that C4 deficiency reduces amyloid plaques and neuroinflammation in a mouse AD model, suggesting C4's role in glial reactivity and pathology.

This study shows that disrupting the central circadian clock in 5xFAD mice under a light-dark cycle reduces amyloid plaque and tau phosphorylation, suggesting a complex interaction between circadian rhythms and Alzheimer's pathology.

The paper identifies cell-type and disease-specific circadian gene expression changes in glial cells under amyloid pathology or aging in mice.

This study shows that microglia drive diurnal variation in BBB permeability during inflammation, with increased BBB breakdown following evening LPS injection.