Michael Lässig

The paper assesses pre-existing humoral immunity against H5N1 clade 2.3.4.4b in unexposed individuals and finds low but distinct cross-neutralizing titers.

This paper analyzes the sequence-dependent energy landscapes of MHC-peptide binding, showing class-specific nonlinearities and their implications for immune recognition and escape.

The paper develops an analytical model to predict microbial resource allocation patterns under different nutrient conditions and identifies a metabolite-based regulatory mechanism for optimal growth.

This paper develops methods to predict viral evolution using integrated data on sequences, epidemiology, antigenicity, and phenotypes, providing vaccine strain selection insights.

The paper shows that the Drosophila genome has two modes of evolution: one with limited linkage effects and one with clonal competition, linked to recombination rates.

The paper investigates how recombination rates influence adaptive evolution in Drosophila, finding higher adaptive substitution rates in high-recombining regions and significant collateral fitness costs in low-recombining regions.