Stephan Uphoff

The paper shows RecA* structure dynamics predict spontaneous cell death in E. coli by linking SOS response magnitude to DNA repair kinetics.

This study uses live-cell single-molecule tracking to measure DNA repair activity in intracellular E. coli and links it to metabolic and biophysical changes during macrophage infection.

This study identifies resistance determinants to antisense antibiotics by analyzing mutations in gram-negative pathogens exposed to CPP-PNA conjugates, revealing adaptation strategies and resistance mechanisms.

The paper investigates how MutH is recruited to DNA for strand incision in E. coli MMR by analyzing its search dynamics in live cells.

This study visualizes the intracellular dynamics of Shigella sonnei's virulence plasmid pINV in real-time using fluorescent tagging.

This study investigates SMCHD1's chromatin interactions and shows LRIF1 and ATPase activity are critical for its selective binding and epigenetic silencing functions.

The paper uses time-resolved single-cell imaging to study the Escherichia coli oxidative stress response, revealing simple regulatory logic in gene expression dynamics.

The paper uses single-molecule imaging to study LexA degradation in E. coli, showing it causes SOS response heterogeneity and spontaneous pulses that improve survival.

This study models how gene expression noise affects the adaptive response to DNA alkylation damage in E. coli, showing that low Ada molecule counts lead to stochastic delays and reduced response strength with higher growth rates.