Dariusz Bartosik

pLAST improves plasmid classification by combining ORF similarity and gene neighborhood conservation, outperforming existing methods in detecting functional modules and types.

This study identifies two categories of extrachromosomal replicons in bacteria and shows that large replicons replicate in sync with the chromosome and use its replication machinery for stable inheritance.

The paper characterizes the replication system of Klebsiella pneumoniae plasmid pIGMS31, revealing its unique mosaic structure combining theta and rolling circle replication modes.