Didier Mazel

This study identifies two categories of extrachromosomal replicons in bacteria and shows that large replicons replicate in sync with the chromosome and use its replication machinery for stable inheritance.

This paper develops conjugative plasmids that block antibiotic resistance plasmid spread by combining metabolic enhancement and plasmid spread mechanisms in microbial communities.

This study shows that positioning RNAP-encoding genes near the replication origin in fast-growing bacteria is essential for optimal growth and gene dosage effects.

The paper identifies accessory PDFs in bacterial genomes that confer resistance to PDF inhibitors and are mobile, posing a challenge for antibiotic development.

This paper maps tRNA modifications in Vibrio cholerae using chemical sequencing and gene deletions, revealing species-specific features and their role in translation and stress responses.

The paper uses experimental evolution to show that circadian clock mutations in cyanobacteria enhance growth under continuous light by altering transcriptomic and metabolic responses.

The paper identifies xildivaline, a novel peptide deformylase inhibitor produced by Gammaproteobacteria, and elucidates its biosynthesis and structural features.

This study shows that extracellular vesicles in E. coli sequester and remove antibiotics, repair membranes, and enhance survival without conferring resistance.

The paper investigates plasmid-chromosome transcriptional interactions in multidrug-resistant bacteria, finding that a plasmid-encoded regulator drives chromosomal operon overexpression, enhancing bacterial fitness and carbapenem resistance dissemination.

The paper investigates how the mechanical stability of the integron synaptic complex affects recombination efficiency in bacteria, finding a strong correlation between stability and efficiency.

The paper shows V. cholerae MatP structures and delays segregation of both chromosomes independently of tetramer formation and divisome interaction.

The paper deletes a chromosomal integron in Vibrio cholerae and shows it has no detectable effect on physiology, proving its genetic and functional isolation.

The paper fine-tunes a CRISPRi screen in Vibrio cholerae to enable pooled genome-wide screening with minimal cytotoxicity and identifies 368 essential genes.

The paper identifies anti-phage defence systems encoded by sedentary chromosomal integron cassettes in Vibrio cholerae, showing 16 cassettes provide phage resistance.

The paper investigates how inverted sedentary chromosomal integrons (SCIs) in Vibrio cholerae recover their original orientation through homologous recombination, maintaining cassette stability and bacterial fitness.

The paper shows toxin-antitoxin systems regulate cassette recombination dynamics in chromosomal integrons by killing cells when excision rates are too high.

The paper demonstrates that integron integrase can insert cassettes outside classical att sites, leading to new recombination sites called attG and expanding integron roles in bacterial evolution.

The paper investigates cassette recruitment in the chromosomal integron of Vibrio cholerae during conjugation and natural transformation, showing that horizontally transferred cassettes can be inserted and expressed.