Author

Simon A. Smith

AstraZeneca (United Kingdom)ORCID 0000-0002-3591-3016Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Demetriou· 1 shared A. Narasimhan· 1 shared A. Rangel· 1 shared A. Tocheva· 1 shared A.M. FarkasiD· 1 shared Alan A. MelcheriD· 1 shared Alan SotoiD· 1 shared Amir HorowitziD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. Demetriou

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 2, 2024

The HLA-E/NKG2A axis identifies a therapeutic vulnerability in BCG-unresponsive bladder cancer

Bérengère Salomé, Haocheng Yu, Daniel L Ranti…·Amir Horowitz

This study identifies the HLA-E/NKG2A axis as a therapeutic target in BCG-unresponsive bladder cancer by showing its role in immune evasion and impaired effector cell function.

5 citations

humanbulk RNA-seq

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ImmunologyNature CommunicationsPeer-reviewedAug 12, 2024

Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent anti-PD-L1- and anti-NKG2A-based adjuvant immunotherapy

Emmanuel Christian Patin, Pablo Nenclares, Charleen Chan Wah Hak…·Kevin Joseph Harrington

This study combines ATR inhibition with radiotherapy and immune checkpoint blockade to enhance antitumour immunity in HNSCC preclinical models.

22 citations

mouseproteomics

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