Author

A. Narasimhan

Icahn School of Medicine at Mount Sinai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Organism:Drosophila· 1

Frequent Co-Authors

A. Bonetto· 2 shared T. Zimmers· 2 shared A. Demetriou· 1 shared A. G. Robling· 1 shared A. L. Mosley· 1 shared A. Rangel· 1 shared A. Tocheva· 1 shared A. Young· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

A. Bonetto

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The HLA-E/NKG2A axis identifies a therapeutic vulnerability in BCG-unresponsive bladder cancer

Bérengère Salomé, Haocheng Yu, Daniel L Ranti, Ying‐Chih Wang, C. Bieber, Pierre‐Etienne Gabriel, Igor Duquesne, Trine Strandgaard, B. Hug, Sean Houghton, Hiranmayi Ravichandran, Elliot Merritt, S. Bang, A. Demetriou, Z. Li, , Amir Horowitz

This study identifies the HLA-E/NKG2A axis as a therapeutic target in BCG-unresponsive bladder cancer by showing its role in immune evasion and impaired effector cell function.

bioRxiv · Sep 2, 2024 · PreprintCancer Biology

Gemcitabine plus nab-paclitaxel preserves skeletal and cardiac mass and function in a murine model of pancreatic cancer cachexia

A. Narasimhan, D. Jengelley, J. Huot, T. Umberger, E. Doud, A. L. Mosley, M. Wang, X. Zhong, B. Counts, J. Rupert, A. Young, A. Bonetto, D. Horan, A. G. Robling, M. Fishel, , T. Zimmers

This study shows that gemcitabine plus nab-paclitaxel reduces tumor burden and prevents muscle and cardiac wasting in a murine model of pancreatic cancer cachexia.

bioRxiv · Apr 15, 2023 · PreprintCancer Biology

IL-6 Trans-Signaling and Tumor-Muscle-Adipose Crosstalk Mediate Pancreatic Cancer Cachexia

J. E. Rupert, A. Bonetto, A. Narasimhan, Y. Liu, T. M. O'Connell, L. G. Koniaris, T. Zimmers

This study identifies IL-6 trans-signaling and tissue crosstalk as drivers of pancreatic cancer cachexia, showing disruption reduces fat and muscle wasting.

bioRxiv · Sep 16, 2020Cancer Biology

PARASITES MEDIATE CONDITION-DEPENDENT SEXUAL SELECTION FOR LOCAL ADAPTATION IN A NATURAL INSECT POPULATION

M. Gomez, A. Narasimhan, E. Svensson

The paper quantifies parasite-mediated sexual selection in a natural insect population and shows increased local adaptation against parasites over time.

bioRxiv · Feb 28, 2019 · PreprintEvolutionary Biology