Amir Horowitz

This study maps human natural killer cell development in tonsil using single-cell analysis, showing spatial trajectories and tissue niches that support NK cell differentiation.

The paper identifies atypical B cells (ABCs) as mediators of poor response to BCG immunotherapy in high-risk NMIBC patients, linking their expansion and FCRL5 expression to early recurrence.

This study identifies inherited genetic risk factors in young-onset lung cancer, finding higher burdens of rare pathogenic variants in DDR and cilia-related genes and elevated polygenic risk scores.

This study shows that VEGF-C promotes lymphangiogenesis in tumors, enhancing immune cell infiltration and enabling complete tumor eradication with viral immunotherapy.

This study identifies the HLA-E/NKG2A axis as a therapeutic target in BCG-unresponsive bladder cancer by showing its role in immune evasion and impaired effector cell function.

This paper uses single-cell RNA-sequencing to analyze the tumor microenvironment in pleural mesothelioma, identifying gene programs, fetal-like endothelial cells, and a new therapeutic target.

The paper creates a single-cell reference map of NK cells and identifies tumor-associated states predictive of patient outcomes in melanoma and osteosarcoma.

This study identifies SLAMF6 signaling suppression in bladder cancer tumor microenvironment as a cause of NK cell dysfunction, showing restoration of function under normoxic conditions.

This study identifies C1QA as a consistent biomarker for tissue macrophages and explores its role in anti-microbial pathways.

This study maps human natural killer cell development in pediatric tonsil using imaging mass cytometry and high-resolution microscopy, revealing stage-specific localization and interactions.

MiDAS is an R package that enables statistical analysis of immunogenetic data, including HLA fine mapping, evolutionary divergence, and HLA-KIR interactions.

The paper identifies proinflammatory monocytes/macrophages associated with resistance to PD-1/PD-L1 blockade in urothelial cancer using bulk and single-cell RNA sequencing.