William C. Wetsel

The paper identifies TAAR1 agonists with antipsychotic-like effects through computational screening and experimental validation, showing improved potency and reduced side effects in a schizophrenia model.

This paper introduces engineered mouse models to study the effects of psychedelic drugs by examining HTR2A receptor expression and function.

The paper identifies SNPs in GPCRs that alter β-arrestin signaling bias and shows their potential impact on phenotypic variation.

This study shows that two doses of Qβ virus-like particle-based vaccines generate protective antibodies against heroin and fentanyl in animal models.

This study shows that combining haloperidol with UNC9994 reduces schizophrenia-like symptoms in NMDAR-deficient mice.

This study shows that presynaptic Rac1 signaling selectively regulates spatial working memory, with distinct effects on synaptic vesicles and morphology compared to postsynaptic Rac1 inhibition.

This paper establishes a multi-stage IVSA paradigm in mice for studying addiction, showing that behavioral traits predict vulnerability to drug seeking and relapse.

This study identifies conserved YKL-40 changes in mice and humans after postoperative delirium, linking systemic and CNS inflammation to neuroimmune interactions.

The paper develops a proximity proteomics method in mice to identify protein interactions relevant to autism, revealing new genetic risk factors and functional interactions.

This study shows that disrupting BCAA metabolism in the nervous system impairs hippocampal neurogenesis and working memory in mice.

This study investigates the role of the NLRP3 inflammasome in postoperative neuroinflammation and evaluates the neuroprotective effects of the ANXA1-derived peptide ANXA1sp in a mouse model of surgery-induced cognitive deficits.

This study investigates how LSD affects behavior in mice lacking beta-arrestin 1 or 2, revealing distinct roles for these proteins in mediating LSD's effects.

This study shows that URMC-099 prevents surgery-induced microglial activation and cognitive decline in a mouse model of PND without affecting bone healing.

The paper shows that GIT2 deficiency does not impair learning and memory due to a brain-specific splice variant that avoids forming GIT/PIX complexes.

This study shows that the cortico-striatal circuit regulates sensorimotor gating through Disc1/Huntingtin-mediated Bdnf transport, with lithium restoring deficits in Disc1-LI mice.

This paper identifies a cellular mechanism involving giant ankyrin-B that leads to stochastic axon projections and contributes to neurodiversity and ASD.