Ding Xuan Zhou

This paper introduces a method to accurately estimate spikes and subthreshold waveforms from 1-photon voltage imaging in vivo, even with noise.

The paper introduces EASE, a method that matches calcium imaging signals to EM-derived cell segments in mouse visual cortex, enabling dendritic functional analysis and denoising.

The paper introduces a zero-inflated gamma model for deconvolved calcium imaging traces, showing it outperforms simpler models in simulated and real neural data.

The paper develops all-optical electrophysiology tools to record subthreshold dynamics and excitability in mouse hippocampus during behavior, revealing brain-state dependent changes in neuronal activity.

~2-4x SNR gains and 20-300x compression on calcium and voltage imaging, from a patch-wise penalized matrix decomposition that splits signal from temporally uncorrelated noise without hyperparameter tuning.