Author

Lichao Sun

Beijing Institute of TechnologyORCID 0000-0002-3621-5252Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Shuyuan GuoiD· 2 shared Yi‐Xin HuoiD· 2 shared Zeyu LiangiD· 2 shared Bo ZhengiD· 1 shared Chaoyong HuangiD· 1 shared Dengtian Cao· 1 shared Hao GuoiD· 1 shared Jing LiiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBioengineering

Shuyuan GuoORCID

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3 papers

Recent·Most cited

BioengineeringiSciencePeer-reviewedApr 17, 2025

Chromosome segment scanning for gain- or loss-of-function screening (CHASING) and its application in metabolic engineering

Yan Xia, Lichao Sun, Zeyu Liang…·Shuyuan Guo

The paper introduces CHASING, a method for gain- or loss-of-function screening using chromosome-segment deletions, and applies it to identify metabolic engineering targets in B. subtilis.

2 citations

bacteria (other)experimental assay

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Synthetic BiologybioRxivPreprintMay 30, 2024

Design nonrepetitive and diverse activity single-guide RNA by deep learning

Yan Xia, Zeyu Liang, Xiaowen Du…·Shuyuan Guo

This study develops a deep learning model to generate nonrepetitive and diverse CRISPR sgRNAs with high activity, validated for gene editing and regulation in Bacillus subtilis.

DOI 10.1101/2024.05.30.596019

bacteria (other)CRISPR screen

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Synthetic BiologyMetabolic EngineeringPeer-reviewedMay 4, 2023

A tRNA Modification-based strategy for Identifying amiNo acid Overproducers (AMINO)

Hao Guo, Ning Wang, Tingting Ding…·Yi‐Xin Huo

This paper introduces a tRNA modification-based strategy to identify amino acid overproducers in microbial hosts.

12 citations

E. coliC. elegans

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