Author
University of CambridgeORCID 0000-0002-3644-9809Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Alexander Röntgen, Giuliana Fusco, Jonathan C. Breiter…·Michele Vendruscolo
Yuqing Feng, Amberley D. Stephens, Pedro Vallejo Ramirez…·Gabriele S. Kaminski Schierle
This study shows α-synuclein modulates spontaneous dopamine release via calcium and phosphorylation-dependent mechanisms, independent of full-fusion recycling.
Yuqing Feng, Bismoy Mazumder, Tasuku Konno…·Gabriele S. Kaminski Schierle
This study shows that 24S-HC and 27-HC, brain cholesterol metabolites, cause neuronal dysfunction in human iPSC-derived neurons by disrupting calcium signaling, organelle function, and alpha-synuclein accumulation.
Maria Zacharopoulou, Neeleema Seetaloo, James F. Ross…·Gabriele S. Kaminski Schierle
This study investigates how Ca2+ and Na+ ions affect alpha-synuclein aggregation and fibril polymorphism, revealing their distinct roles in modulating conformational dynamics and structural outcomes.
Sonia Donzelli, Sinéad A. O’Sullivan, Anne‐Laure Mahul‐Mellier…·Hilal Ahmed Lashuel
This study shows that nitration of alpha-synuclein after fibrillization reduces its seeding activity and pathology formation in neurons and in vivo.
Súil Collins, Liisa van Vliet, Fabrice Gielen…·Gabriele S. Kaminski Schierle
The paper develops a unified in vitro to in vivo fluorescence lifetime screening platform to identify amyloid β aggregation inhibitors, revealing a new compound effective in multiple models.