Amanda Bentley‐DeSousa

This study shows that PIKfyve inhibition enhances LRRK2 signaling via ClC-7-dependent lysosomal remodeling and Rab accumulation, revealing distinct Rab and GABARAP inputs for LRRK2 activation under different lysosomal stresses.

The paper shows that VPS13C senses lysosome damage, relocates to lysosomes, and tethers them to the ER, suggesting a protective lipid transport response.

This study identifies a STING-CASM-GABARAP pathway that activates LRRK2 at lysosomes in response to lysosomal stress and links it to disease relevance in Parkinson's and Crohn's disease.

The paper identifies TBK1's role in lysosomal signaling, showing it phosphorylates Rab7 to relieve mTORC1 inhibition in response to amino acids.

The paper shows that the AP-3 complex is required for Vtc5 localization to the vacuole membrane in yeast, and its mislocalization leads to decreased polyP levels.

The paper identifies 8 new polyphosphorylated proteins in yeast, including vacuolar proteins, and suggests a feedback regulation model for polyP synthesis.