Shawn M. Ferguson

This study investigates the roles of CSTN1 and CSTN3 in axonal cargo transport, finding they coordinate TGN exit and regulate RAB6A levels to influence Golgi organization and trafficking.

The paper identifies TMEM106B fibril accumulation as a shared mechanism in neurodegeneration linked to genetic variants in TMEM106B and GRN.

This study identifies lysosomal swelling as a trigger for LRRK2-mediated Rab phosphorylation, independent of membrane damage or PIKfyve inhibition.

This study shows that PIKfyve inhibition enhances LRRK2 signaling via ClC-7-dependent lysosomal remodeling and Rab accumulation, revealing distinct Rab and GABARAP inputs for LRRK2 activation under different lysosomal stresses.

This study shows that JIP4 deficiency causes lysosomal cystine accumulation by reducing CTNS levels, mimicking cystinosis in human cells and mice.

This study identifies LRP10 as a regulator of progranulin and prosaposin lysosomal trafficking and microglia homeostasis, linking its dysfunction to neurodegenerative diseases.

The paper shows that VPS13C senses lysosome damage, relocates to lysosomes, and tethers them to the ER, suggesting a protective lipid transport response.

This study identifies a STING-CASM-GABARAP pathway that activates LRRK2 at lysosomes in response to lysosomal stress and links it to disease relevance in Parkinson's and Crohn's disease.

The paper identifies TBK1's role in lysosomal signaling, showing it phosphorylates Rab7 to relieve mTORC1 inhibition in response to amino acids.

This study identifies nutrient signaling pathways that regulate amyloid clearance and synaptic loss in Alzheimer's disease, showing both protective and harmful effects.