Lucrezia Patruno

The paper shows how epigenetic heritability of cell plasticity contributes to cancer drug resistance through a one-to-many genotype-to-phenotype mapping.

CONGAS+ is a Bayesian method that maps single-cell RNA and ATAC data to copy number clones, revealing subclonal architectures and genotype-phenotype relationships in cancer.

CONGAS clusters single-cell RNA sequencing data using copy number alterations to infer subclonal composition and RNA phenotypes in cancer data.

The paper introduces two Cytoscape-based tools, cyTRON and cyTRON/JS, for inferring cancer evolution models from genomic and proteomics data.