Martine Simonelig

This study identifies piRNAs and the PIWI protein Aubergine as regulators of glycolytic metabolism in Drosophila germline stem cells.

The paper shows that Drosophila germ granules have a biphasic organization where translation occurs in the outer phase, and mRNA localization depends on their translation status.

This study identifies RNF219 as an interacting partner of the CCR4-NOT complex that modulates its translational repression activity through deadenylation-independent mechanisms.

This study identifies a new role for the PIWI protein Aubergine in promoting nanos mRNA translation by interacting with eIF3 and PABP in Drosophila germ plasm.

This study shows Aubergine and piRNAs repress Cbl mRNA translation to regulate germline stem cell self-renewal and differentiation in Drosophila.

This study shows Orb represses autophagy in Drosophila germline by inhibiting Atg12 mRNA translation, preventing cell death during early oogenesis.