Shai Shaham

The paper identifies MYRF-1 as a regulator of non-apoptotic linker cell death in C. elegans, showing its role in priming death through activation of pqn-41/polyQ.

This study identifies EOR-1/PLZF as a regulator of WAH-1/AIF, which sequentially promotes non-apoptotic corpse removal during development.

The paper identifies CEH-43/DLX as a key regulator of radial-glia-to-astrocyte trans-differentiation in C. elegans and mouse, showing its role in transcriptional convergence.

The paper shows that CED-3 caspase in C. elegans promotes non-apoptotic linker cell dismantling but not death onset, and reveals similar mechanisms in mouse cells.

The paper investigates the role of mitochondrial transport by kinesin motors in preventing localized calcium spiking and caspase-dependent cell death during specialized elimination in C. elegans neurons.

The paper identifies LET-381/FoxF and DMD-4/DMRT as regulators of HMC endothelial cell fate in C. elegans.

The paper shows that glia in C. elegans detect and respond to dendrite structure damage by altering gene expression and secreting proteins, with specific proteins required for this response.

This study identifies astrocyte-derived extracellular matrix proteins, particularly SPARC, as regulators of synapse remodeling in stress-induced depression.

This study identifies LET-381/FoxF and UNC-30/Pitx2 as key regulators of C. elegans mesodermal glia development and function, showing their role in motor behavior regulation.

This study shows that small RNAs can be inherited transgenerationally in C. elegans without nuclear factors or chromatin changes, mediated by ZNFX-1 and germ granules.

The paper identifies a cell-division-independent pathway for epithelial-to-motoneuron transformation in C. elegans, revealing regulatory mechanisms involving Notch, Ngn, and cytoskeletal genes.

The paper shows that inherited small RNAs in C. elegans regulate sexual attraction and outcrossing rates across generations, influencing population genetics under stress.

The paper identifies UNC-130 as a lineage-specific repressor that enables convergent differentiation in C. elegans by allowing proper specification of glial cells from distinct lineages.

This study shows that glia actively engulf neuron fragments in C. elegans, affecting neuron shape and thermosensory behavior through a molecular pathway involving PS receptors and GTPase signaling.