Author
Harvard UniversityORCID 0000-0001-6518-5470Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
6 papers
Recent·Most cited
Julia M. Rogers, Claudia A. Mimoso, Benjamin J. E. Martin…·Stephen C. Blacklow
This study shows Notch1 activates transcription by releasing paused RNA Pol II without requiring chromatin accessibility changes.
Kian Hong Kock, Patrick K. Kimes, Stephen S. Gisselbrecht…·Martha L. Bulyk
The paper analyzes DNA binding effects of 92 human homeodomain mutants, identifying 14 novel specificity-determining residues and highlighting limitations of variant effect prediction tools.
Lena Tveriakhina, Gustavo Scanavachi, Emily D. Egan…·Stephen C. Blacklow
This study tracks Notch and Delta interactions in real-time, showing 1:1 stoichiometry at synapses and NICD nuclear entry after 45 minutes, inhibited by signaling blockers.
Alexandre P. J. Martin, Gary Andrew Bradshaw, Robyn J. Eisert…·Stephen C. Blacklow
This study maps the spatiotemporal dynamics of Notch2 signaling from membrane to nucleus after ligand activation, identifying key molecular events in signal transmission.
Karolina Mizeracka, Julia M. Rogers, Jonathan D. Rumley…·Maxwell G. Heiman
The paper identifies UNC-130 as a lineage-specific repressor that enables convergent differentiation in C. elegans by allowing proper specification of glial cells from distinct lineages.
Julia M. Rogers, Bingqian Guo, Emily D. Egan…·Stephen C. Blacklow
The paper investigates the differential requirements for MAML1 in Notch-dependent transcription at HES4 and DTX1, showing distinct functional roles of MAML1 regions and interactions with p300.