Yiyang Chen

This paper develops a human recombinant antibody (3G11) specific for DRP1-S616 phosphorylation, demonstrating its utility in detecting mitochondrial division in cancer, particularly in BRAFV600E-associated diseases.

The paper identifies a hydrophobic funnel in BAX that binds 2t-hexadecenal, enhancing BAX activation with BIM, and shows proline 168 regulates this interaction.

This study shows that leukemia cells rely on increased mitochondrial respiration for survival when glucose uptake is acutely inhibited by KL-11743.

The paper presents a high-yield protocol for expressing, purifying, and storing functional monomeric BAX protein, addressing challenges in its production and stability.