Katia Cosentino

This study identifies GSDME-N as a mediator of mitochondrial inner membrane permeabilization and mtDNA release during apoptosis, revealing its structural mechanism and impact on inflammatory responses.

This study challenges models of ceramide-induced apoptosis by showing ceramides cannot form channels or substitute for cardiolipin in Bax pore formation.

This paper shows FGF2 oligomerization drives PI(4,5)P2 partitioning and membrane pore formation, enabling FGF2 translocation across the plasma membrane.

The paper visualizes GSDMD nanostructures at the plasma membrane of pyroptotic cells and identifies PI(3,4,5)P3 as a regulator of pore formation.