Hugo Daniel Luján

This study shows that IL-1R2 on Tfr cells prevents excessive activation and allergy by limiting IgE and promoting IgG responses.

The paper benchmarks neoantigen immunogenicity predictors and finds that MHC-I binding affinity and its derived metrics are insufficient to predict immunogenicity or tumor neoantigen burden as biomarkers.

MIXTURE improves immune tumor microenvironment estimation by reducing overestimation of cell-type counts and improving accuracy in bulk RNA data.