Author

Sandii Constable

The University of Texas Southwestern Medical CenterORCID 0000-0002-3809-4976Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Carolyn M. OttiD· 2 shared Jennifer Lippincott‐SchwartziD· 2 shared Kevin WhiteiD· 2 shared Saikat MukhopadhyayiD· 2 shared Alyssa Bushey LongiD· 1 shared Amin Lim· 1 shared Andrew L. LemireiD· 1 shared Katharine A. FloydiD· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

Carolyn M. OttORCID

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3 papers

Recent·Most cited

Cell BiologyProceedings of the National Academy of SciencesPeer-reviewedDec 20, 2024

Programmed withdrawal of cilia maintenance followed by centriole capping leads to permanent cilia loss during cerebellar granule cell neurogenesis

Sandii Constable, Carolyn M. Ott, Andrew L. Lemire…·Saikat Mukhopadhyay

The paper identifies a programmed cilia deconstruction pathway in cerebellar granule cells during neurogenesis, showing decreased cilia maintenance and centriole capping prevent cilia regrowth and dysregulated signaling.

17 citations

mousescRNA-seq

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Cell BiologyThe Journal of Cell BiologyPeer-reviewedJun 27, 2024

Permanent deconstruction of intracellular primary cilia in differentiating granule cell neurons

Carolyn M. Ott, Sandii Constable, Tri Nguyen…·Saikat Mukhopadhyay

The paper investigates ciliary dynamics in differentiating granule cell neurons, finding that cilia are deconstructed intracellularly and do not reform in adult neurons.

34 citationstop 2%

mouseelectronic health records

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Developmental BiologyDevelopmentPeer-reviewedJan 21, 2020

Ciliary phosphatidylinositol phosphatase Inpp5e plays positive and negative regulatory roles in Shh signaling

Sandii Constable, Alyssa Bushey Long, Katharine A. Floyd…·Tamara Caspary

The paper identifies Inpp5e's dual role in Shh signaling by showing it regulates GliA and GliR timing, affecting neural tube patterning.

30 citations

mouseexperimental assay

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