John M. Koomen

The paper develops microtumor models from lung cancer samples to study EMT and metabolic changes, identifying fatty acid synthesis as a targetable vulnerability.

This study identifies TROLL-8 as a regulator of fatty acid oxidation in breast cancer, showing its role in promoting tumorigenesis through CPT1A interaction.

This study identifies that CAFs confer ALK inhibitor resistance in EML4-ALK-driven lung cancer through both MET and integrin signaling pathways, and shows that targeting both pathways improves treatment efficacy.

This study shows TAp73 regulates lipid metabolism in lung tumor microenvironment to enhance anti-tumor immunity through T-cell activation.

This study shows that combining RET and SRC inhibitors enhances anti-cancer effects in RET fusion-positive cancers by suppressing PAK signaling and restoring sensitivity in resistant cells.

This study identifies branched-chain keto acid accumulation in leptomeningeal disease CSF, showing immune suppression and neurodegeneration, and shows that reducing BCKA improves outcomes in mouse models.